What is a "women's issue"? An issue that affects only women? There's no such thing. Women don't live in a vacuum; most of them have men in their lives -- a father, brother, husband or son -- who are affected, to some degree, by anything that affects the women they love.
Well, then, is it an issue that only women are interested in? Again, there's no such thing. Every father wants to see his daughter given an equal opportunity at success; no husband wants to see his wife sexually harassed at work; no son wants to see his mother humiliated or beaten.
It should go without saying that men's and women's lives are inextricably intertwined, therefore their concerns are intertwined. But some things are so basic that we forget to focus on them. So, I'll say it, just for emphasis: Anything that affects women affects the men who love them; anything that affects men affects the women who love them. But, the topic of this site is not "everything," it is "women's issues," so it's necessary to come up with some workable definition of a "women's issue." Here's mine: A women's issue is an issue that affects women more than men, and/or an issue that women are more likely to care about than men are. This is still a broad list, but it's manageable.
A list of issues fitting these criteria immediately springs to mind. Equal opportunity, sexual harassment, and domestic violence are only the beginning of the list. Each and every decision to have, or not have, an abortion eventually comes down to one woman's personal conscience and beliefs. No-fault divorce allows women to escape abusive relationships, but often lowers their standard of living as well. Discrimination against lesbians and lesbian couples is as close to an issue that affects only women as we can get (the concern of male friends and relatives aside). Gender bias in both language and education affects young girls for years, perhaps their whole lives. Women are dying to match media images of super-thin models.
In the broader context of our American culture, women are more likely than men to be concerned about access to affordable and safe child care, for two reasons: First, in households where both parents work, child care is still primarily the responsibility of the woman; and second, more single-parent households are headed by women than by men. Additionally, in those single-parent households, more single mothers than single fathers are in jobs without insurance coverage. Clearly, health care for uninsured children can also be considered a "women's issue."
This is not a complete list, of course, and some of these issues are already being covered in depth and detail by other About.com Guides. This list merely serves as an example of the application of my own personal criteria, and provides a place to begin.